I noticed that when I use Yatse with kodi19 on Google Chromecast with TV 2021 it somehow prevents the Chromecast communication with the Chromecast remote on wake-up or on standby always after it has not being used for long time.
If my tv is on, after a while if I want to navigate with the Chromecast control it doesn’t respond. I need to navigate with Yatse first or any other digital controler on the network ( like the Android TV app).
If I uninstall Yatse then there is no problem it works.
Any idea how to solve this?
Without logs not much I can tell 
https://yatse.tv/wiki/debug-yatse-kodi-remote
But I have no idea what you are talking about Yatse can not have any impact on the physical remote for the Chromecast that use Bluetooth. I’m using that combination nearly every day without issue.
After reading again, you are not even casting but just running Kodi.
Sounds like a bug on Kodi side. You can uncheck the option Use event server in Yatse host configuration so that Yatse only use HTTP to talk to Kodi.
But your issue is definitively caused by Kodi and only them would be able to do anything to fix it.